香港大學孫紅哲教授做客第271期化苑講壇

 報告題目：Integrative-omics approach for metals in medicine

報 告 人 ：孫紅哲教授

報告時間：2017年6月16日（周五）下午15:00

報告地點：化學樓二樓一號會議室

邀 請 人 ：劉紅梅教授

報告人簡介：

    孫紅哲教授，1996年獲倫敦大學博士學位，現(xiàn)為香港大學化學系教授、博導，中山大學“計劃”獲得者、國家杰出青年基金獲得者，先后榮獲香港裘槎基金會“裘槎杰出研究者獎”、香港大學杰出研究者獎以及香港大學杰出研究生導師獎。主要從事化學與生物、醫(yī)學的交叉前沿研究，擅長生物無機化學、金屬組學/金屬蛋白質組學及金屬蛋白質的結構生物學。迄今發(fā)表論文150余篇，總引用達6000余次，h因子大于43。

報告內容：

    Metal ions play crucial roles in life processes either as an essential elements or therapeutical/diagnostic agents. It is crucial to identify metal-protein interactions at a proteome-wide scale which are difficult due to certain weak and transient interactions. We developed an integrated approach consisting of gel electrophoresis and inductively coupled plasma mass spectrometry, immobilized metal affinity chromatography (IMAC), fluorescence and bioinformatics to identify metal-associated proteins using bismuth antiulcer drug as an example. We have identified metal-associated proteins as well as to quantify the metals for fast metallome/proteome-wide profiling of metal-binding proteins. The multi-targets of bismuth(III) provide a rational basis in understanding the high efficacy and low antibiotic resistance of this class of bismuth drugs. We also show that an integrative metallomic approach represents a powerful tool for metals in biology and medicine as well as pharmacology of metallodrugs.