報(bào)告題目：Synthetic biology: from small molecular discovery, production to the creating of conditional knockout animal models

報(bào) 告 人 ：Pinghua Liu

報(bào)告時(shí)間：2017年12月21日（周四）上午10:00

報(bào)告地點(diǎn)：化學(xué)樓二樓一號(hào)會(huì)議

邀 請(qǐng) 人 ：廖榮臻教授

報(bào)告人簡(jiǎn)介：

Prof. Pinghua Liu received his B.S. in 1993 from Nankai University, M.S. in 1996 from Dalian Institute of Chemical Physics, and PhD in 2001 from University of Minnesota, USA. Then, he worked as a postdoc at Massachusetts Institute of Technology during 2001-2005. In 2005, he joined Department of Chemistry in Boston University as an Assistant Professor and was promoted to Associate Professor in 2011. He has published about 40 papers in international journals, including Nature, Annu. Rev. Biochem., Curr. Opin. Chem. Biol., J. Am. Chem. Soc. and Angew. Chem. Int. Ed. He has received the NSF Career Award (2008-2013).

報(bào)告摘要：

To date, natural products are still the main source of human medicine. In the post genome era, there is a renewed interest on natural product studies because genome information revealed that we touch only a tiny portion of the natural product pools. In the presentation, we will summarize our recent efforts in natural product based drug discovery efforts in the following three areas:

1) Molecular discovery: in this area, we focus on how to efficiently build natural product library that is not feasible through traditional approach;

2) Process chemistry: in this area, we will summarize some of our recent efforts on developing fermentation based production methods for high value products.

3) Animal model: for drug discovery efforts, proper animal is crucial. In this portion, we will discuss our efforts on creation of new conditional knockout animal models for our natural product based drug discovery efforts.