報(bào)告題目：Helical Foldamers: Highly Modular Scaffolds for Molecular Recognition

報(bào) 告 人 ：Yann Ferrand教授

報(bào)告時(shí)間：2018年5月29日上午10:00

報(bào)告地點(diǎn)：化學(xué)樓二樓一號(hào)會(huì)議室

邀 請 人 ：甘泉教授

報(bào)告人簡介：

Yann Ferrand is a CNRS researcher and a group leader at the Institute of Chemistry and Biology of Membranes and Nano-objects of the University of Bordeaux (France). He was appointed as a CNRS research associate in 2007. He studied chemistry at the University of Rennes (France) where he received his PhD degree in 2005. Then, he worked as a post-doc in the School of Chemistry of the University of Bristol (United Kingdom) from 2005 until 2007. His research focuses on the design and synthesis of synthetic macromolecules (e.g. foldamers) for the recognition of complex molecular targets and their use as sensors. He has published over 50 peer reviewer articles; Science (2), Nat. Chem. (1), Nature Nanotech. (1), Angew. Chem. (10), J. Am. Chem. Soc. (6)

報(bào)告簡介：

Our group has developed helical foldamers – oligomers that adopt stable helical folded conformations – derived from aromatic amino acids. Some of these folded objects have shown unprecedented conformational stability even in water, and constitute convenient building blocks to elaborate synthetic, very large (protein-sized) folded architectures. Cavities can be designed within such synthetic molecules that enable them to act as artificial receptors for chiral polar guests. This design offers unmatched modularity in that each and every monomer may be varied in order to tune the structure, the dynamics and host-guest properties. Iterative evolution of oligoamide sequences was used to develop receptors able to bind a given guest with high affinity and selectivity. Rounds of selection have been made possible through the extensive use of crystallography, NMR and circular dichroism.